Impaired release of beta-endorphin in response to serotonin in a rat model of depression.

@article{Zangen2002ImpairedRO,
  title={Impaired release of beta-endorphin in response to serotonin in a rat model of depression.},
  author={Abraham Zangen and Rachel A Nakash and Ilana Roth-Deri and David H. Overstreet and Gal Yadid},
  journal={Neuroscience},
  year={2002},
  volume={110 3},
  pages={389-93}
}
Involvement of both the serotonergic and the endogenous opioid systems in the onset of depressive behavior has been suggested. Previously we showed that serotonin (5-hydroxytryptamine) facilitates beta-endorphin release in the nucleus accumbens (NAcc). Herein, the microdialysis method was used to assess in vivo the effects of serotonin on beta-endorphin release in a rat model of depressive behavior (the Flinders sensitive line, FSL), before and after antidepressant treatment. The basal… CONTINUE READING