Impaired regulatory T cell function in germ-free mice.

  title={Impaired regulatory T cell function in germ-free mice.},
  author={Sofia Ostman and Carola Rask and Agnes E. Wold and Susanne Hultkrantz and Esbj{\"o}rn Telemo},
  journal={European journal of immunology},
  volume={36 9},
Regulatory T cells (Treg) are crucial for the maintenance of tolerance to auto-antigens and harmless exogenous antigens. Here, we studied the role of the commensal microbiota for the development and function of Treg. CD4+CD25+ T cells were obtained from peripheral lymph nodes (PLN) and mesenteric lymph nodes (MLN) of germ-free (GF) and conventional (conv) NMRI mice and tested for phenotype and functional suppressive capacity. CD4+CD25+ T cells from GF mice showed a lower relative gene… CONTINUE READING

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