Impaired regulation of stride variability in Parkinson's disease subjects with freezing of gait

  title={Impaired regulation of stride variability in Parkinson's disease subjects with freezing of gait},
  author={Jeffrey M. Hausdorff and Joanna D. Schaafsma and Yacov Balash and Anna L. Bartels and Tanya Gurevich and Nir Giladi},
  journal={Experimental Brain Research},
Patients with Parkinson's disease (PD) often experience freezing of gait, a debilitating phenomenon during which the subject suddenly becomes unable to start walking or to continue to move forward. Little is known about the gait of those subjects with PD who experience freezing of gait or the pathophysiology of freezing. One possibility is that freezing of gait is a truly paroxysmal phenomenon and that the usual walking pattern of subjects who experience freezing of gait is not different than… 

Increased foot strike variability in Parkinson's disease patients with freezing of gait.

The role of gait rhythmicity and bilateral coordination of stepping in the pathophysiology of freezing of gait in Parkinson's disease

It is proposed that impairments in the ongoing regulation of gait, even during periods in which freezing is not present, set the stage for the occurrence of a FOG episode.

Noisy Interlimb Coordination Can Be a Main Cause of Freezing of Gait in Patients with Little to No Parkinsonism

Compared gait patterns during straight walking between 9 patients with freezing of gait but little to no parkinsonism and 11 patients with Parkinson’s disease suggest that noisy interlimb coordination can affect regulation of the gait cycle.

Is Freezing of Gait in Parkinson's Disease a Result of Multiple Gait Impairments? Implications for Treatment

This work proposes distinct categories of interventions which aim to maintain a good level of locomotion control especially with respect to aspects related to FOG; and those that merely aim to escape from FOG once it occurs.

Does freezing in Parkinson’s disease change limb coordination?

The side of the body where gait terminated before freezing was in most cases the side of symptom-dominance, but not consistently so, and body side differences were larger than sequential deterioration of consecutive steps within each side.

What Can We Learn From Freezing of Gait in Parkinson’s Disease?

It is possible that FOG in PD represents the ultimate break in the frontal lobe–basal ganglia–cerebellar–brainstem network that controls gait, and likely is the primary and continuous abnormality of “the gait network” in PD.

Quantifying freezing of gait in Parkinson's disease during the instrumented timed up and go test

FoG was quantified from the power spectral density of the antero-posterior shank acceleration and the Frequency Ratio was validated as significantly correlated with self-perceived severity of gait and balance confidence.



Dynamic markers of altered gait rhythm in amyotrophic lateral sclerosis.

It is found that the gait of patients with ALS is less steady and more temporally disorganized compared with that of healthy controls, and stride-to-stride control of gait rhythm is apparently compromised with ALS.

Abnormalities of the spatiotemporal characteristics of gait at the onset of freezing in Parkinson's disease

Results suggest that freezing is caused by a combination of an increasing inability to generate stride length superimposed on a dyscontrol of the cadence of walking.

The pathogenesis of gait hypokinesia in Parkinson's disease.

It was concluded that regulation of stride length is the fundamental problem in gait hypokinesia and the relative increase in cadence exhibited by PD subjects is a compensatory mechanism for the difficulty in regulating stride length.

Freezing of gait in Parkinson's disease.

Freezing of gait in PD: Prospective assessment in the DATATOP cohort

Objective To study the development of freezing of gait in PD. BackgroundFreezing of gait is a common, disabling, and poorly understood symptom in PD. MethodsThe authors analyzed data from 800

Gait variability and basal ganglia disorders: Stride‐to‐stride variations of gait cycle timing in parkinson's disease and Huntington's disease

Findings are consistent with a differential control of gait variability, speed, and average gait cycle timing that may have implications for understanding the role of the basal ganglia in locomotor control and for quantitatively assessing gait in clinical settings.

Construction of freezing of gait questionnaire for patients with Parkinsonism.

Normal frontal perfusion in patients with frozen gait

  • N. FabreC. Brefel O. Rascol
  • Medicine, Biology
    Movement disorders : official journal of the Movement Disorder Society
  • 1998
The results do not support the hypothesis that start hesitations and freezing when walking are related to a frontal lobe dysfunction, however, it is possible that frontal neuronla dysfunction occurs without measurable cerebral blood flow changes in the resting condition.

Fall Risk Factors in Parkinson's Disease

  • P. GrayK. Hildebrand
  • Medicine, Psychology
    The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses
  • 2000
Duration and severity of PD symptoms, particularly freezing, involuntary movements, and walking and postural difficulties, were significantly associated with an increased risk of falls and other factors associated with falls were postural hypotension and daily intake of alcohol.

Freezing phenomenon in patients with parkinsonian syndromes

  • Nir GiladiR. KaoS. Fahn
  • Medicine, Psychology
    Movement disorders : official journal of the Movement Disorder Society
  • 1997
Of 347 patients with a clinical diagnosis of parkinsonism other than idiopathic Parkinson's disease and with specific data regarding freezing, 158 patients had freezing (46%) and freezing was significantly associated with progression of the disease as rated on the Hoehn & Yahr scale.