Impaired recruitment of seizure-generated neurons into functional memory networks of the adult dentate gyrus following long-term amygdala kindling.

@article{Fournier2013ImpairedRO,
  title={Impaired recruitment of seizure-generated neurons into functional memory networks of the adult dentate gyrus following long-term amygdala kindling.},
  author={Neil M. Fournier and Justin J Botterill and Wendie N. Marks and Axel J Guskjolen and Lisa E. Kalynchuk},
  journal={Experimental neurology},
  year={2013},
  volume={244},
  pages={96-104}
}
Epileptic seizures increase the birth of new neurons in the adult hippocampus. Although the consequences of aberrant neurogenesis on behavior are not fully understood, one hypothesis is that seizure-generated neurons might form faulty circuits that disrupt hippocampal functions, such as learning and memory. In the present study, we employed long-term amygdala kindling (i.e., rats receive 99-electrical stimulations) to examine the effect of repeated seizures on hippocampal neurogenesis and… CONTINUE READING