Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

@article{Lyden2001ImpairedRO,
  title={Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth},
  author={David Lyden and Koichi Hattori and S{\'e}rgio Luiz Vaz Dias and Carla Maria Costa and Pamela Blaikie and Linda J Butros and Amy Chadburn and Beate Heissig and Willy Marks and Larry Witte and Yan Wu and Daniel J. Hicklin and Zhenping Zhu and Neil R. Hackett and Ronald G. Crystal and Malcolm A. S. Moore and Katherine A Hajjar and Katia Manova and Robert Benezra and Shahin Rafii},
  journal={Nature Medicine},
  year={2001},
  volume={7},
  pages={1194-1201}
}
The role of bone marrow (BM)-derived precursor cells in tumor angiogenesis is not known. We demonstrate here that tumor angiogenesis is associated with recruitment of hematopoietic and circulating endothelial precursor cells (CEPs). We used the angiogenic defective, tumor resistant Id-mutant mice to show that transplantation of wild-type BM or vascular endothelial growth factor (VEGF)-mobilized stem cells restore tumor angiogenesis and growth. We detected donor-derived CEPs throughout the… CONTINUE READING