Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala

  title={Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala},
  author={Ralph Adolphs and Daniel Tranel and Hanna Damasio and Antonio R. Damasio},
STUDIES in animals have shown that the amygdala receives highly processed visual input1,2, contains neurons that respond selectively to faces3, and that it participates in emotion4,5 and social behaviour6. Although studies in epileptic patients support its role in emotion7, determination of the amygdala's function in humans has been hampered by the rarity of patients with selective amygdala lesions8. Here, with the help of one such rare patient, we report findings that suggest the human… 
Recognition of facial emotion in nine individuals with bilateral amygdala damage
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Although the amygdala is widely believed to have a role in the recognition of emotion, a central issue concerns whether it is involved in the recognition of all emotions or whether it is more
A Role for the Human Amygdala in Recognizing Emotional Arousal From Unpleasant Stimuli
The findings suggest that the amygdala plays a critical role in knowledge concerning the arousal of negative emotions, a function that may explain the impaired recognition of fear and anger in patients with bilateral amygdala damage, and one that is consistent with the amygdala's role in processing stimuli related to threat and danger.
Normal recognition of emotional similarity between facial expressions following bilateral amygdala damage
Fear and the human amygdala
The results show that bilateral, but not unilateral, damage to the human amygdala impairs the processing of fearful facial expressions, and it is proposed that the amygdala is required to link visual representations of facial expressions with representations that constitute the concept of fear.
Expression Without Recognition: Contributions of the Human Amygdala to Emotional Communication
A case study of a patient with bilateral amygdaloid damage who, despite a severe deficit in interpreting facial expressions of emotion including fear, exhibits an intact ability to express this and other basic emotions suggests that a single neural module does not support all aspects of the social communication of emotional state.
A neuromodulatory role for the human amygdala in processing emotional facial expressions.
Functional neuroimaging confirmed that the amygdala and some of its functionally connected structures mediate specific neural responses to fearful expressions and demonstrated that amygdalar responses predict expression-specific neural activity in extrastriate cortex.
Impaired auditory recognition of fear and anger following bilateral amygdala lesions
A further investigation is reported of one of these rare cases, a woman who has impaired perception of the intonation patterns that are essential to the perception of vocal affect, despite normal hearing, which shows that the amygdala's role in the recognition of certain emotions is not confined to vision, which is consistent with its being involved in the appraisal of danger and the emotion of fear.


Intact recognition of facial expression, gender, and age in patients with impaired recognition of face identity
It is concluded that the cognitive demands posed by different forms of recognition are met at different processing levels, and different levels depend on different neural substrates.
Neuropsychological correlates of bilateral amygdala damage.
An extensive neuropsychological investigation in a patient with bilateral amygdala damage due to Urbach-Wiethe disease showed that she had normal electrodermal activity, an important finding in view of the role that has been attributed to the amygdala in the central control of autonomic responses.
Multidimensional scaling of emotional facial expressions: Similarity from preschoolers to adults.
Structural models of emotion represent the fact that we perceive emotions as systematically interrelated. These interrelations may reveal a basic property of the human conception of emotions, or they
The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction.
The Amygdala and Social Behaviour Meidal Temporal Lobe Structures Contributing to Recognition Memory: The Amygdaloid Complex Versus the Rhinal Cortex and the Functional Effects of Amygdala Lesions in Humans Kindling and the Amygdala.
Emotional memory systems in the brain
Face agnosia and the neural substrates of memory.
Face agnosia, along with the varied neuropsychological disturbances that may accompany it, can now be analyzed with experimental paradigms and correlated with neuroanatomical loci of damage identified by neuroimaging methods, providing a rare opportunity to elucidate cognitive and neural mechanisms of perception, learning, and memory in humans.
The role of the amygdala in fear and anxiety.
  • M. Davis
  • Biology, Psychology
    Annual review of neuroscience
  • 1992
The idea that the amygdala, and its many efferent projections, may represent a central fear system involved in both the expression and acquisition of conditioned fear is summarized.