Impaired protection against Mycobacterium bovis bacillus Calmette-Guerin infection in IL-15-deficient mice.

@article{Saito2006ImpairedPA,
  title={Impaired protection against Mycobacterium bovis bacillus Calmette-Guerin infection in IL-15-deficient mice.},
  author={Kimika Saito and Toshiki Yajima and Shino Kumabe and Takehiko Doi and Hisakata Yamada and Subash Sad and Hao Shen and Yasunobu Yoshikai},
  journal={Journal of immunology},
  year={2006},
  volume={176 4},
  pages={2496-504}
}
To investigate the potential role of endogenous IL-15 in mycobacterial infection, we examined protective immunity in IL-15-deficient (IL-15(-/-)) mice after infection with Mycobacterium bovis bacillus Calmette-Guérin (BCG) or recombinant OVA-expressing BCG (rBCG-OVA). IL-15(-/-) mice exhibited an impaired protection in the lung on day 120 after BCG infection as assessed by bacterial growth. CD4(+) Th1 response capable of producing IFN-gamma was normally detected in spleen and lung of IL-15… CONTINUE READING
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