Impaired proliferative potential of bone marrow mesenchymal stromal cells in patients with myelodysplastic syndromes is associated with abnormal WNT signaling pathway.

@article{Pavlaki2014ImpairedPP,
  title={Impaired proliferative potential of bone marrow mesenchymal stromal cells in patients with myelodysplastic syndromes is associated with abnormal WNT signaling pathway.},
  author={Konstantia I. Pavlaki and Charalampos G Pontikoglou and Anthi Demetriadou and Aristea K. Batsali and Athina Damianaki and Emmanouil Simantirakis and Michail Kontakis and Athanasios Galanopoulos and Ioannis Kotsianidis and Maria-Christina Kastrinaki and Helen A. Papadaki},
  journal={Stem cells and development},
  year={2014},
  volume={23 14},
  pages={1568-81}
}
It has been shown that bone marrow mesenchymal stromal cells (MSCs) from patients with myelodysplastic syndromes (MDSs) display defective proliferative potential. We have probed the impaired replicative capacity of culture-expanded MSCs in MDS patients (n=30) compared with healthy subjects (n=32) by studying senescence characteristics and gene expression associated with WNT/transforming growth factor-β1 (TGFB1) signaling pathways. We have also explored the consequences of the impaired patient… CONTINUE READING