Impaired proinsulin processing is a characteristic of transplanted islets.

  title={Impaired proinsulin processing is a characteristic of transplanted islets.},
  author={Agnieszka M Klimek and Galina Soukhatcheva and David M Thompson and Garth L. Warnock and Maryam Salehi and Horacio Rilo and David D'Alessio and Graydon S Meneilly and Constadina Panagiotopoulos and C Bruce Verchere},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  volume={9 9},
We sought to determine whether recipients of islet transplants have defective proinsulin processing. Individuals who had islet allo- or autotransplantation were compared to healthy nondiabetic subjects. Insulin (I), total proinsulin (TP), intact proinsulin and C-peptide (CP) were measured in samples of fasting serum by immunoassay, and the ratios of TP/TP+I and TP/CP were calculated. Islet allotransplant recipients had elevated TP levels relative to nondiabetic controls (16.8 [5.5-28.8] vs. 8.4… CONTINUE READING


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