• Biology, Medicine
  • Published in Journal of immunology 1985

Impaired production of gamma-interferon by newborn cells in vitro is due to a functionally immature macrophage.

@article{Taylor1985ImpairedPO,
  title={Impaired production of gamma-interferon by newborn cells in vitro is due to a functionally immature macrophage.},
  author={Stephen C. Taylor and Yvonne Bryson},
  journal={Journal of immunology},
  year={1985},
  volume={134 3},
  pages={
          1493-7
        }
}
The decreased production of gamma-(PHA-induced) interferon (IFN) by leukocytes of normal newborns could be due to functionally immature T cells, macrophages, or both. We studied gamma-IFN production by macrophages and T cells, alone and in combination, obtained from 50 cord blood samples and 14 adult blood samples in a series of experiments. Adherent macrophages were cultivated for 7 days before the addition of T cells. After 48 hr, PHA-stimulated macrophage-T cell supernatants were harvested… CONTINUE READING

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