Impaired presynaptic regulation of norepinephrine in schizophrenia. Effects of clonidine in schizophrenic patients and normal controls.

@article{Sternberg1982ImpairedPR,
  title={Impaired presynaptic regulation of norepinephrine in schizophrenia. Effects of clonidine in schizophrenic patients and normal controls.},
  author={David E. Sternberg and Dennis S. Charney and George R. Heninger and James F. Leckman and K M Hafstad and DeWitt Landis},
  journal={Archives of general psychiatry},
  year={1982},
  volume={39 3},
  pages={285-9}
}
Recent studies have found elevated levels of norepinephrine (NE) in CSF and brain specimens from schizophrenic patients. Presynaptic inhibitory alpha 2-adrenergic receptors regulate NE release in the brain. The hypothesis that the functional sensitivity of this presynaptic regulation of NE is impaired in schizophrenia was tested by evaluating, in schizophrenic patients and age-matched normal controls, the ability of clonidine, an alpha 2 agonist, to lower plasma levels of the NE metabolite 3… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Psychotic Continuum

Springer Berlin Heidelberg • 1995

Schizoaffective Psychoses

Springer Berlin Heidelberg • 1986

Similar Papers

Loading similar papers…