Impaired prepulse inhibition of acoustic startle in obsessive-compulsive disorder.

  title={Impaired prepulse inhibition of acoustic startle in obsessive-compulsive disorder.},
  author={Klaus Hoenig and Andrea Hochrein and Boris B. Quednow and Wolfgang Maier and Michael Wagner},
  journal={Biological psychiatry},
  volume={57 10},
BACKGROUND Animal and clinical studies suggest that impaired sensorimotor gating, as assessed with the prepulse inhibition (PPI) paradigm, may result from dysfunctional frontostriatal brain circuits and from neurochemical alterations which are also implied in the pathophysiology of obsessive-compulsive disorder (OCD). However, there is only preliminary evidence about impaired PPI in OCD so far. METHODS Acoustic PPI was measured in 30 OCD patients and 30 matched healthy controls with a… CONTINUE READING
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