Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease.

@article{Swerdlow1995ImpairedPI,
  title={Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease.},
  author={Neal R. Swerdlow and J Kevin Paulsen and David L. Braff and Nelson Butters and Mark A. Geyer and Michael R. Swenson},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={1995},
  volume={58 2},
  pages={
          192-200
        }
}
The corpus striatum serves a critical function in inhibiting involuntary, intrusive movements. Striatal degeneration in Huntington's disease results in a loss of motor inhibition, manifested by abnormal involuntary choreiform movements. Sensorimotor inhibition, or "gating", can be measured in humans using the startle reflex: the startle reflex is normally inhibited when the startling stimulus is preceded 30-500 ms earlier by a weak prepulse. In the present study, prepulse inhibition (PPI) was… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 47 references

Effects of frontal cortex and hippocampal lesions on apomorphine - disrupted startle gating

  • NR Swerdlow, B Lipska, D Weinberger, DL Braff, JaskiwG, MA Geyer
  • Biol Psychiatry
  • 1994

Clozapine improves sensory gating more than haldol

  • JC Wu, SG Potkin, DI Ploszaj, V Lau, J Telford, G Richmond
  • 1993

Gating deficits , neural circuits , and schizophrenia

  • DL Braff, MA Geyer, NR Swerdlow, T Jemigan
  • Biol Psychiatry
  • 1993

Limbic cortico - striato - pallido - pontine substrates of startle gating

  • NR Swerdlow, F Wan, M Kodsi, H Hartston, S Caine
  • Biol Psychiatry
  • 1993