Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease.

  title={Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease.},
  author={Neal R. Swerdlow and J Kevin Paulsen and David L. Braff and Nelson Butters and Mark A. Geyer and Michael R. Swenson},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  volume={58 2},
The corpus striatum serves a critical function in inhibiting involuntary, intrusive movements. Striatal degeneration in Huntington's disease results in a loss of motor inhibition, manifested by abnormal involuntary choreiform movements. Sensorimotor inhibition, or "gating", can be measured in humans using the startle reflex: the startle reflex is normally inhibited when the startling stimulus is preceded 30-500 ms earlier by a weak prepulse. In the present study, prepulse inhibition (PPI) was… CONTINUE READING
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