Impaired plasma B-type natriuretic peptide clearance in human septic shock.

@article{Pirracchio2008ImpairedPB,
  title={Impaired plasma B-type natriuretic peptide clearance in human septic shock.},
  author={Romain Pirracchio and Nicolas Deye and Anne Claire Lukaszewicz and Alexandre Mebazaa and Bernard P. Cholley and Joaquim Mateo and Bruno M{\'e}garbane and Jean Marie Launay and Jacqueline Peynet and Fr{\'e}d{\'e}ric J. Baud and Didier M. Payen},
  journal={Critical care medicine},
  year={2008},
  volume={36 9},
  pages={2542-6}
}
INTRODUCTION High B-type natriuretic peptide (BNP) levels are reported in the context of septic shock. We hypothesized that high BNP levels might be related to an alteration in BNP clearance pathway, namely neutral endopeptidase (NEP) 24.11. NEP 24.11 activity was measured in septic shock and in cardiogenic shock patients. We further evaluated whether baseline plasma BNP can predict fluid responsiveness and whether BNP can still be released in plasma despite high initial BNP levels, in response… CONTINUE READING
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