Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment.

@article{Singh2004ImpairedPF,
  title={Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment.},
  author={Inderjit Singh and Ajaib Singh Paintlia and Mushfiquddin Khan and Romesh Stanislaus and Manjeet Kaur Paintlia and Ehtishamul Haq and Avtar Kaur Singh and Miguel Agustin Contreras},
  journal={Brain research},
  year={2004},
  volume={1022 1-2},
  pages={1-11}
}
Peroxisomes are ubiquitous subcellular organelles and abnormality in their biogenesis and specific gene defects leads to fatal demyelinating disorders. We report that neuroinflammatory disease in brain of experimental autoimmune encephalomyelitis (EAE) rats decreased the peroxisomal functions. Degradation of very long chain fatty acids decreased by 47% and resulted in its accumulation (C26:0, 40%). Decreased activity (66% of control) of dihydroxyacetonephosphate acyltransferase (DHAP-AT), first… CONTINUE READING

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