Impaired p65 degradation by decreased chaperone-mediated autophagy activity facilitates epithelial-to-mesenchymal transition

Abstract

Aberrant activation of nuclear factor-κB (NF-κB) has been observed in a wide range of human cancers and is thought to promote tumorigenesis and metastasis. As a central component of NF-κB pathway, p65 protein level is tightly regulated and could be subjected to proteasome degradation. Here we demonstrated that p65 can bind to HSC70 with four consensus… (More)
DOI: 10.1038/oncsis.2017.85

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Cite this paper

@inproceedings{Tang2017ImpairedPD, title={Impaired p65 degradation by decreased chaperone-mediated autophagy activity facilitates epithelial-to-mesenchymal transition}, author={J. Tang and M-N Zhan and Q-Q Yin and C-X Zhou and C-L Albert Wang and L-L Wo and M. He and G-Q Chen and Q. Zhao}, booktitle={Oncogenesis}, year={2017} }