Impaired oxidative phosphorylation in skeletal muscle of intrauterine growth-retarded rats.

@article{Selak2003ImpairedOP,
  title={Impaired oxidative phosphorylation in skeletal muscle of intrauterine growth-retarded rats.},
  author={Mary A. Selak and Bayard T. Storey and Iyalla E Peterside and Rebecca A. Simmons},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2003},
  volume={285 1},
  pages={E130-7}
}
Intrauterine growth retardation (IUGR) has been linked to the development of type 2 diabetes in later life. We have developed a model of uteroplacental insufficiency, a common cause of intrauterine growth retardation, in the rat. Early in life, the animals are insulin resistant and by 6 mo of age they develop diabetes. Glycogen content and insulin-stimulated 2-deoxyglucose uptake were significantly decreased in muscle from IUGR rats. IUGR muscle mitochondria exhibited significantly decreased… CONTINUE READING