Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats.

@article{Peterside2003ImpairedOP,
  title={Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats.},
  author={Iyalla E Peterside and Mary A. Selak and Rebecca A. Simmons},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2003},
  volume={285 6},
  pages={E1258-66}
}
Intrauterine growth retardation (IUGR) has been linked to the development of type 2 diabetes in adulthood. We have developed an IUGR model in the rat whereby the animals develop diabetes between 3 and 6 mo of age that is associated with insulin resistance. Alterations in hepatic glucose metabolism are known to contribute to the hyperglycemia of diabetes; however, the mechanisms underlying this phenomenon have not been fully explained. To address this issue, intact liver mitochondria were… CONTINUE READING
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Aberrant insulin-mediated hepatic glucose production in growth-retarded rats (Abstract)

  • P Vuguin, B Liu, N Barzilai, R. Simmons
  • Pediatr Res 51:
  • 2002
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