Impaired oxidation of pyruvate in human embryonic fibroblasts after exposure to L-dopa.

@article{Werner1994ImpairedOO,
  title={Impaired oxidation of pyruvate in human embryonic fibroblasts after exposure to L-dopa.},
  author={Petra Werner and Catherine Mytilineou and Gerald Cohen and Melvin D. Yahr},
  journal={European journal of pharmacology},
  year={1994},
  volume={263 1-2},
  pages={157-62}
}
The effect of 3,4-dihydroxyphenylalanine (L-dopa) treatment on the ability of intact human cells to metabolize substrates for mitochondrial oxidative phosphorylation was studied in embryonic fibroblasts. Treatment with L-dopa (100-400 microM) for 48 h significantly reduced the oxidation of pyruvate but had no effect on succinate oxidation. The effect was dose-dependent and was still present 2 days after removal of L-dopa. Ascorbic acid (200 microM) protected the cells from the effects of L-dopa… CONTINUE READING