Impaired off-line memory consolidation in depression.

  title={Impaired off-line memory consolidation in depression.},
  author={Martin Dresler and Michael Kluge and Lisa Genzel and Petra Schuessler and Axel Steiger},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  volume={20 8},
Sleep is critically involved in the consolidation of procedural memory. In major depression (MD) and during antidepressant pharmacotherapy, changes in sleep EEG are well documented. Here, we test if off-line motor memory consolidation is impaired in MD. 50 medicated patients with an acute episode of MD, 50 normal controls and 12 patients with a remitted episode of MD were assessed using a sequential finger tapping task before and after a night of sleep. Although depressed patients and control… CONTINUE READING

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