Impaired notch signaling promotes de novo squamous cell carcinoma formation.

@article{Proweller2006ImpairedNS,
  title={Impaired notch signaling promotes de novo squamous cell carcinoma formation.},
  author={Aaron Proweller and Lili Tu and John J. Lepore and Lan Cheng and Min Min Lu and John T Seykora and Sarah E. Millar and Warren S Pear and Michael S. Parmacek},
  journal={Cancer research},
  year={2006},
  volume={66 15},
  pages={7438-44}
}
Signaling through Notch receptors in the skin has been implicated in the differentiation, proliferation, and survival of keratinocytes, as well as in the pathogenesis of basal cell carcinoma (BCC). To determine the composite function of Notch receptor-mediated signaling in the skin and overcome potential redundancies between receptors, conditional transgenic mice were generated that express the pan-Notch inhibitor, dominant-negative Mastermind Like 1 (DNMAML1), to repress all canonical [CBF-1… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 50 references

Notch1 functions as a tumor suppressor in mouse skin

Nature Genetics • 2003
View 5 Excerpts
Highly Influenced

Notch signaling is an important regulator of type 2 immunity

The Journal of experimental medicine • 2005
View 2 Excerpts

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