Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase.

@article{Lin2002ImpairedNO,
  title={Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase.},
  author={Ken Y Lin and Akira Ito and Tomoko Asagami and Philip S. Tsao and Shanthi Adimoolam and Masumi Kimoto and Hideaki Tsuji and Gerald Mark Reaven and John P Cooke},
  journal={Circulation},
  year={2002},
  volume={106 8},
  pages={987-92}
}
BACKGROUND An endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA), is elevated in patients with type 2 diabetes mellitus (DM). This study explored the mechanisms by which ADMA becomes elevated in DM. METHODS AND RESULTS Male Sprague-Dawley rats were fed normal chow or high-fat diet (n=5 in each) with moderate streptozotocin injection to induce type 2 DM. Plasma ADMA was elevated in diabetic rats (1.33+/-0.31 versus 0.48+/-0.08 micromol/L; P<0.05). The activity… CONTINUE READING
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Homocysteine impairs the NO synthase pathway: role of ADMA

  • MC Stühlinger, PS Tsao, J-H Her
  • Circulation
  • 2001

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