Impaired neutrophils in children with the typical form of hemolytic uremic syndrome

@article{Fernndez2005ImpairedNI,
  title={Impaired neutrophils in children with the typical form of hemolytic uremic syndrome},
  author={Gabriela Cristina Fern{\'a}ndez and Sonia Alejandra G{\'o}mez and Carolina J. Rubel and Leticia Ver{\'o}nica Bentancor and Paula Barrionuevo and Marta Aldunc{\'i}n and Irene A Grimoldi and Ramon Alfonso Exeni and Mart{\'i}n Amadeo Isturiz and Marina Sandra Palermo},
  journal={Pediatric Nephrology},
  year={2005},
  volume={20},
  pages={1306-1314}
}
Experimental and clinical evidence suggest that activated neutrophils (PMN) could contribute to endothelial damage in Hemolytic Uremic Syndrome (D+HUS). Additionally, while PMN-activating cytokines and PMN-derived products have been found in D+HUS sera, we have demonstrated phenotypic alterations in D+HUS PMN compatible with a deactivation state. Here, we investigated whether D+HUS PMN were actually hyporesponsive, and explored some of the mechanisms probably involved in their derangement… CONTINUE READING
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