Impaired neuronal operation through aberrant intrinsic plasticity in epilepsy

@article{Artinian2015ImpairedNO,
  title={Impaired neuronal operation through aberrant intrinsic plasticity in epilepsy},
  author={Julien Artinian and Ang{\'e}lique Peret and Yanina Mircheva and Geoffrey Marti and Val{\'e}rie Cr{\'e}pel},
  journal={Annals of Neurology},
  year={2015},
  volume={77}
}
Patients with temporal lobe epilepsy often display cognitive comorbidity with recurrent seizures. However, the cellular mechanisms underlying the impairment of neuronal information processing remain poorly understood in temporal lobe epilepsy. Within the hippocampal formation neuronal networks undergo major reorganization, including the sprouting of mossy fibers in the dentate gyrus; they establish aberrant recurrent synapses between dentate granule cells and operate via postsynaptic kainate… 
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A Network Model Reveals That the Experimentally Observed Switch of the Granule Cell Phenotype During Epilepsy Can Maintain the Pattern Separation Function of the Dentate Gyrus
TLDR
This chapter explains the concepts of pattern separation and how it was tested in the DG model, a conductance-based neural network model of the brain circuit thought to be involved in pattern separation during hippocampal memory acquisition: the dentate gyrus.
Position- and Time-Dependent Arc Expression Links Neuronal Activity to Synaptic Plasticity During Epileptogenesis
TLDR
During epileptogenesis epileptic activity emerges early and persists in the whole hippocampus, however, only the sclerotic part shows modulation of discharge amplitudes accompanied by plasticity of DGCs, identified as a putative mediator between seizure activity and synaptic plasticity.
Synaptic Reshaping and Neuronal Outcomes in the Temporal Lobe Epilepsy
  • Elisa Ren, G. Curia
  • Biology, Psychology
    International journal of molecular sciences
  • 2021
TLDR
This review provides an overview of the structural and functional alterations of synaptic connections in the brain of TLE/mTLE patients and animal models.
Kainate and AMPA receptors in epilepsy: Cell biology, signalling pathways and possible crosstalk
Bad Timing for Epileptic Networks: Role of Temporal Dynamics in Seizures and Cognitive Deficits
TLDR
Evidence is presented that in epilepsy, failed coordination leads not only to seizures but also to alterations of the rhythmical patterns observed in the electroencephalogram and cognitive deficits, and restoring the dynamic coordination of epileptic networks could improve seizures and cognitive outcomes.
Abnormal motor cortex plasticity in juvenile myoclonic epilepsy
Behavior‐associated Neuronal Activation After Kainic Acid‐induced Hippocampal Neurotoxicity is Modulated in Time
TLDR
Information is provided on the long‐term modifications associated to structural plasticity and neuronal activation in the dentate gyrus after excitotoxic damage and in face of a spatial‐exploratory behavior.
Functional relevance of homeostatic intrinsic plasticity in neurons and networks
TLDR
A homeostatic regulation of membrane ion channel conductances is shown to maintain the intrinsic excitability of neurons, which is crucial for stable brain activity.
Kainate Receptors: Role in Epilepsy
Kainate (KA) is a potent neurotoxin that has been widely used experimentally to induce acute brain seizures and, after repetitive treatments, as a chronic model of temporal lobe epilepsy (TLE), with…
The Kainic Acid Models of Temporal Lobe Epilepsy
TLDR
The advantages and limitations of the various forms of KA administration, as well as the histologic, electrophysiological, and behavioral outcomes in different strains and species, are discussed.
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