Impaired neuroglial activation in interleukin-6 deficient mice.

  title={Impaired neuroglial activation in interleukin-6 deficient mice.},
  author={Marguerite A Klein and Jens Carsten M{\"o}ller and Leonard L. Jones and Horst Bluethmann and Georg W. Kreutzberg and Gennadij Raivich},
  volume={19 3},
Astrocyte activation is a ubiquitous hallmark of the damaged brain and has been suggested to play an important regulatory role in the activation, survival, and regeneration of adjacent neurons, microglia, and oligodendrocytes. Little is known, however, about the endogenous signals that lead to this activation of astrocytes. Here we examined the regulation of interleukin 6 (IL6), a proinflammatory cytokine, its receptors, and the effects of IL6-deficiency in a model of traumatic central nervous… CONTINUE READING
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