Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice.

@article{Rgnier2002ImpairedNT,
  title={Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice.},
  author={Catherine H. R{\'e}gnier and R{\'e}gis Masson and Val{\'e}rie K{\'e}dinger and Julien Textoris and I. Katharina Stoll and M -P Chenard and Andr{\'e}e Di{\'e}rich and Catherine Tomasetto and M. C. Rio},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 8},
  pages={5585-90}
}
TRAF4 belongs to the tumor necrosis factor receptor-associated factor (TRAF) family of proteins but, unlike other family members, has not yet been clearly associated to any specific receptor or signaling pathway. To investigate the biological function of TRAF4, we have generated traf4-deficient mice by gene disruption. The traf4 gene mutation is embryonic lethal but with great individual variation, as approximately one third of the homozygous mutant embryos died in utero around embryonic day 14… CONTINUE READING

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Development (Cambridge, U.K

  • M. Mahlapuu, S. Enerback, P. Carlsson
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