Impaired nerve regeneration in streptozotocin-diabetic rats is improved by treatment with gangliosides.


The rate of sciatic nerve regeneration and the effect of ganglioside treatment thereon were studied in the streptozotocin-diabetic rat. Two experimental protocols were used. In the first, sciatic nerves were crushed at 3 weeks of diabetes and treatment with purified bovine brain gangliosides (10 mg/kg/day ip) was begun the day before crush. In the second… (More)


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