Impaired negative regulation of homeostatically proliferating T cells.

  title={Impaired negative regulation of homeostatically proliferating T cells.},
  author={Anna Shvets and Rabindranath Chakrabarti and Rosana Gonzalez-Quintial and Roberto Baccala and Argyrios N. Theofilopoulos and Gerald Joseph Prud'homme},
  volume={113 3},
Acute lymphopenia-induced homeostatic proliferation (HP) of T cells promotes antitumor immunity, but the mechanism is unclear. We hypothesized that this is due to a lack of inhibitory signals that allows activation of T cells with low affinity for self-antigens. Tumors resist immunity in part by expressing inhibitory molecules such as PD-1 ligand 1 (PD-L1), B7-H4, and TGF-beta. In irradiated mice undergoing HP, we found that T cells displayed a severe deficit in the activation-induced… CONTINUE READING

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