Impaired myogenic constriction of the renal afferent arteriole in a mouse model of reduced βENaC expression.

@article{Ge2012ImpairedMC,
  title={Impaired myogenic constriction of the renal afferent arteriole in a mouse model of reduced βENaC expression.},
  author={Ying Ge and Kimberly P Gannon and Monette U. Gousset and Ruishing Liu and Beau S Murphey and Heather A. Drummond},
  journal={American journal of physiology. Renal physiology},
  year={2012},
  volume={302 11},
  pages={F1486-93}
}
Previous studies demonstrate a role for β epithelial Na(+) channel (βENaC) protein as a mediator of myogenic constriction in renal interlobar arteries. However, the importance of βENaC as a mediator of myogenic constriction in renal afferent arterioles, the primary site of development of renal vascular resistance, has not been determined. We colocalized βENaC with smooth muscle α-actin in vascular smooth muscle cells in renal arterioles using immunofluorescence. To determine the importance of… CONTINUE READING
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