Impaired muscle growth and response to insulin-like growth factor 1 in dysferlin-mediated muscular dystrophy.

Abstract

Loss-of-function mutations in dysferlin cause muscular dystrophy, and dysferlin has been implicated in resealing membrane disruption in myofibers. Given the importance of membrane fusion in many aspects of muscle function, we studied the role of dysferlin in muscle growth. We found that dysferlin null myoblasts have a defect in myoblast-myotube fusion… (More)
DOI: 10.1093/hmg/ddq522

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