Impaired motor learning performance in cerebellar En-2 mutant mice.

  title={Impaired motor learning performance in cerebellar En-2 mutant mice.},
  author={Robert Gerlai and Kathleen J. Millen and Karl Herrup and K Fabien and Alexandra L. Joyner and John Roder},
  journal={Behavioral neuroscience},
  volume={110 1},
Mice homozygous for a null mutation in their En-2 gene exhibit cerebellar neuroanatomical alterations including absence and misplacements of specific fissures and size reduction. The present study investigated cerebellar function by comparing the behavior of age-matched homozygous and heterozygous En-2 mutant and wild-type mice. Motor function of the mutants was found normal in several situations. Habituation to novelty in the open field was not significantly different in mutants. However, in a… CONTINUE READING