Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.

@article{Boring1997ImpairedMM,
  title={Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.},
  author={Landin Boring and Jennifa Gosling and Stephen W. Chensue and Steven L. Kunkel and Robert V Farese and Hal E. Broxmeyer and Israel F. Charo},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 10},
  pages={2552-61}
}
Monocyte chemoattractant protein-1 (MCP-1) is a potent agonist for mononuclear leukocytes and has been implicated in the pathogenesis of atherosclerosis and granulomatous lung disease. To determine the role of MCP-1 and related family members in vivo, we used homologous recombination in embryonic stem cells to generate mice with a targeted disruption of C-C chemokine receptor 2 (CCR2), the receptor for MCP-1. CCR2-/- mice were born at the expected Mendelian ratios and developed normally. In… CONTINUE READING
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