Impaired mitochondrial function and oxidative stress in rat cortical neurons: implications for gadolinium-induced neurotoxicity.

@article{Feng2010ImpairedMF,
  title={Impaired mitochondrial function and oxidative stress in rat cortical neurons: implications for gadolinium-induced neurotoxicity.},
  author={Xudong Feng and Qing Xia and Lan Yuan and Xiaoda Yang and Kui Wang},
  journal={Neurotoxicology},
  year={2010},
  volume={31 4},
  pages={391-8}
}
Gadolinium (Gd), a rare-earth lanthanides metal, is widely utilized for various industrial and medical purposes, particularly in brain magnetic resonance imaging. However, its potential effects on the impairment of the central nervous system remain uncertain, especially with regard to the mitochondria, the potential primary target in metal-induced neural injury. This study investigates the effects of gadolinium on mitochondrial energy metabolism, ROS accumulation, and cell death toward cortical… CONTINUE READING
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