Impaired mitochondrial function, oxidative stress and altered antioxidant enzyme activities following traumatic spinal cord injury.

@article{Azbill1997ImpairedMF,
  title={Impaired mitochondrial function, oxidative stress and altered antioxidant enzyme activities following traumatic spinal cord injury.},
  author={Robert D. Azbill and Xiaojun Mu and Annadora J Bruce-Keller and Mark P. Mattson and Joe E Springer},
  journal={Brain research},
  year={1997},
  volume={765 2},
  pages={283-90}
}
Glutamate-induced excitotoxicity involving the formation of reactive oxygen species (ROS) has been implicated in neuronal dysfunction and cell loss following ischemic and traumatic injury to the central nervous system (CNS). ROS are formed in mitochondria when energy metabolism is compromised, and are inactivated by the ROS scavengers superoxide dismutase (SOD), catalase, and glutathione (GSH). ROS can impair the function of several cellular components including proteins, nucleic acids, and… CONTINUE READING
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