Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart

@article{Yan2013ImpairedMB,
  title={Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart},
  author={Wen-jun Yan and Haifeng Zhang and Peilin Liu and Han Wang and Jingyi Liu and Chengyong Gao and Yiqing Liu and Kun Lian and Lu Yang and Lu Sun and Yunping Guo and Lijian Zhang and Ling Dong and Wayne Bond Lau and E. Mei Gao and Feng Gao and Lize Xiong and Haichang Wang and Yan Qu and Ling Jie Tao},
  journal={Basic Research in Cardiology},
  year={2013},
  volume={108},
  pages={1-15}
}
Impaired mitochondrial biogenesis causes skeletal muscle damage in diabetes. However, whether and how mitochondrial biogenesis is impaired in the diabetic heart remains largely unknown. Whether adiponectin (APN), a potent cardioprotective molecule, regulates cardiac mitochondrial function has also not been previously investigated. In this study, electron microscopy revealed significant mitochondrial disorders in ob/ob cardiomyocytes, including mitochondrial swelling and cristae disorientation… CONTINUE READING

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