Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins

@article{Hirsch1996ImpairedMB,
  title={Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins},
  author={Emilio Hirsch and Antonio Iglesias and Alexandra J. Potocnik and Ursula Hartmann and Reinhard F{\"a}ssler},
  journal={Nature},
  year={1996},
  volume={380},
  pages={171-175}
}
ADHESIVE interactions mediated by integrins of the β1 subfamily1 are thought to be critical in controlling differentiation and migration of blood cell precursors2–7. Here we report that chimaeric mice generated with β1-integrin-deficient embryonic stem (ES) cells8,9 lack β−/− cells in blood and in haematopoietic organs such as spleen, thymus and bone marrow. Chimaeric embryos contain β1,-null haematopoietic cells in the yolk sac and in fetal blood but not in fetal liver. We show that such… CONTINUE READING
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