Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis.

@article{Zhang2007ImpairedMO,
  title={Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis.},
  author={Wei Vivian Zhang and Iqbal Ramzan and Michael Murray},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={322 2},
  pages={770-7}
}
Hepatic lipid infiltration (steatosis) is a complication of the metabolic syndrome and can progress to nonalcoholic steatohepatitis and severe liver injury. Microsomal cytochrome P450 (P450) drug oxidases are down-regulated in experimental steatosis. In this study we evaluated the separate and combined effects of lipid accumulation and P450 down-regulation on the microsomal oxidation of the antipsychotic agent clozapine (CLZ), the use of which is associated with an increased incidence of the… CONTINUE READING

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