Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes

  title={Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes},
  author={M. Balasubramanyam and S. Aravind and K. Gokulakrishnan and P. Prabu and C. Sathishkumar and H. Ranjani and V. Mohan},
  journal={Molecular and Cellular Biochemistry},
  • M. Balasubramanyam, S. Aravind, +4 authors V. Mohan
  • Published 2011
  • Medicine
  • Molecular and Cellular Biochemistry
  • Type 2 diabetes patients exhibit subclinical inflammation but the regulatory mechanisms are poorly understood. We sought to evaluate the role of miR-146a expression along with its downstream proinflammatory signals in relation to glycemic control and insulin resistance. Study subjects (n = 20 each) comprised of clinically well characterized Type 2 diabetes patients and control non-diabetic subjects. miRNA and mRNA expression levels were probed in peripheral blood mononuclear cells (PBMC) by… CONTINUE READING
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