Impaired mechanical stability, migration and contractile capacity in vimentin-deficient fibroblasts.

  title={Impaired mechanical stability, migration and contractile capacity in vimentin-deficient fibroblasts.},
  author={Beate Eckes and D Dogic and Emma Colucci-Guyon and Ningning Wang and Andrew Maniotis and Donald E. Ingber and A Merckling and Francina Langa and Monique Aumailley and Annie Delouv{\'e}e and Victor Koteliansky and Charles Babinet and Thomas Krieg},
  journal={Journal of cell science},
  volume={111 ( Pt 13)},
Loss of a vimentin network due to gene disruption created viable mice that did not differ overtly from wild-type littermates. Here, primary fibroblasts derived from vimentin-deficient (-/-) and wild-type (+/+) mouse embryos were cultured, and biological functions were studied in in vitro systems resembling stress situations. Stiffness of -/- fibroblasts was reduced by 40% in comparison to wild-type cells. Vimentin-deficient cells also displayed reduced mechanical stability, motility and… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 179 extracted citations


Publications referenced by this paper.
Showing 1-10 of 52 references

Control of cell and nuclear shape by mechanical stresses transmitted from integrins to the nucleus over direct cytoskeletal interconnections

  • A. J. Maniotis, C. S. Chen, D. E. Ingber
  • Proc. Nat. Acad. Sci. USA
  • 1997
Highly Influential
5 Excerpts

Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro

  • E. Bell, B. Ivarsson, C. Merill
  • Proc. Nat. Acad. USA
  • 1979
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…