Impaired mechanical stability, migration and contractile capacity in vimentin-deficient fibroblasts.

@article{Eckes1998ImpairedMS,
  title={Impaired mechanical stability, migration and contractile capacity in vimentin-deficient fibroblasts.},
  author={Beate Eckes and D Dogic and Emma Colucci-Guyon and Ningning Wang and Andrew Maniotis and Donald E. Ingber and A Merckling and Francina Langa and Monique Aumailley and Annie Delouv{\'e}e and Victor Koteliansky and Charles Babinet and Thomas Krieg},
  journal={Journal of cell science},
  year={1998},
  volume={111 ( Pt 13)},
  pages={1897-907}
}
Loss of a vimentin network due to gene disruption created viable mice that did not differ overtly from wild-type littermates. Here, primary fibroblasts derived from vimentin-deficient (-/-) and wild-type (+/+) mouse embryos were cultured, and biological functions were studied in in vitro systems resembling stress situations. Stiffness of -/- fibroblasts was reduced by 40% in comparison to wild-type cells. Vimentin-deficient cells also displayed reduced mechanical stability, motility and… CONTINUE READING
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