Impaired mammary gland development and function in mice lacking LAR receptor-like tyrosine phosphatase activity.

@article{Schaapveld1997ImpairedMG,
  title={Impaired mammary gland development and function in mice lacking LAR receptor-like tyrosine phosphatase activity.},
  author={Roel Q.J. Schaapveld and Jan T. G. Schepens and Gertraud W. Robinson and Joline Attema and Frank T. J. J. Oerlemans and Jack A. M. Fransen and Michel Streuli and B. Wieringa and Lothar Hennighausen and Wiljan Hendriks},
  journal={Developmental biology},
  year={1997},
  volume={188 1},
  pages={134-46}
}
The LAR receptor-like protein tyrosine phosphatase is composed of two intracellular tyrosine phosphatase domains and a cell adhesion molecule-like extracellular region containing three immunoglubulin-like domains in combination with eight fibronectin type-III-like repeats. This architecture suggests that LAR may function in cellular signalling by the regulation of tyrosine phosphorylation through cell-cell or cell-matrix interactions. We used gene targeting in mouse embryonic stem cells to… CONTINUE READING