Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3.

@article{Behr2007ImpairedMF,
  title={Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3.},
  author={Ruediger Behr and Sara Dutton Sackett and Irina M Bochkis and Phillip P. Le and Klaus H. Kaestner},
  journal={Developmental biology},
  year={2007},
  volume={306 2},
  pages={636-45}
}
Foxa1, 2 and 3 (formerly HNF-3alpha, -beta and -gamma) constitute a sub-family of winged helix transcription factors with multiple roles in mammalian organ development. While all three Foxa mRNAs are present in endoderm derivatives including liver and pancreas, only Foxa3 is expressed in the testis. Here we demonstrate by genetic lineage tracing that Foxa3 is expressed in postmeiotic germ and interstitial Leydig cells. The germinal epithelium of Foxa3-deficient testes is characterized by a loss… CONTINUE READING

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