Impaired lysosomal cobalamin transport in Alzheimer's disease.

  title={Impaired lysosomal cobalamin transport in Alzheimer's disease.},
  author={Hua Zhao and Hongyun Li and Kalani R Ruberu and Brett Garner},
  journal={Journal of Alzheimer's disease : JAD},
  volume={43 3},
Cobalamin (vitamin B12) is required for erythrocyte formation and DNA synthesis and it plays a crucial role in maintaining neurological function. As a coenzyme for methionine synthase and methylmalonyl-CoA mutase, cobalamin utilization depends on its efficient transit through the intracellular lysosomal compartment and subsequent delivery to the cytosol and mitochondria. Lysosomal function deteriorates in Alzheimer's disease (AD). Lysosomal acidification is defective in AD and lysosomal… CONTINUE READING
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