Impaired lymphatic cerebrospinal fluid absorption in a rat model of kaolin-induced communicating hydrocephalus.

@article{Nagra2008ImpairedLC,
  title={Impaired lymphatic cerebrospinal fluid absorption in a rat model of kaolin-induced communicating hydrocephalus.},
  author={Gurjit Nagra and Jianguo Li and James Pat McAllister and Joana Miller and Mark E. Wagshul and Miles G Johnston},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2008},
  volume={294 5},
  pages={R1752-9}
}
It has been assumed that the pathogenesis of hydrocephalus includes a cerebrospinal fluid (CSF) absorption deficit. Because a significant portion of CSF absorption occurs into extracranial lymphatics located in the olfactory turbinates, the purpose of this study was to determine whether CSF transport was compromised at this location in a kaolin-induced communicating (extraventricular) hydrocephalus model in rats. Under 1-3% halothane anesthesia, kaolin (n = 10) or saline (n = 9) was introduced… CONTINUE READING
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Quantification of cerebrospinal fluid transport across the cribriform plate into R1758 HYDROCEPHALUS AND LYMPHATIC CSF ABSORPTION AJP-Regul

  • G Nagra, L Koh, A Zakharov, D Armstrong, M. Johnston
  • Integr Comp Physiol
  • 2008
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