Impaired long-term potentiation in c-Jun N-terminal kinase 2-deficient mice.

@article{Chen2005ImpairedLP,
  title={Impaired long-term potentiation in c-Jun N-terminal kinase 2-deficient mice.},
  author={Ju-Tao Chen and Da-hua Lu and Chern-Pang Chia and Di-yun Ruan and Kanaga T. Sabapathy and Zhi-cheng Xiao},
  journal={Journal of neurochemistry},
  year={2005},
  volume={93 2},
  pages={463-73}
}
c-Jun N-terminal kinases (JNKs) are thought to be involved in regulating synaptic plasticity. We therefore investigated the specific role of JNK2 in modulating long-term potentiation (LTP) in hippocampus during development, using JNK2-deficient mice. The morphological structure and the numbers of both NeuN, a specific neuronal marker, and GABA-positive neurons in the hippocampal areas were similar in wild-type and Jnk2(-/-) mice. Western blot analysis revealed that JNK2 expression was higher… CONTINUE READING