Impaired long-term expansion and self-renewal potential of pediatric acute myeloid leukemia-initiating cells by PTK787/ZK 222584.

@article{Weidenaar2013ImpairedLE,
  title={Impaired long-term expansion and self-renewal potential of pediatric acute myeloid leukemia-initiating cells by PTK787/ZK 222584.},
  author={Alida Cornelia Weidenaar and Arja ter Elst and Kim Rosalie Kampen and Tiny G. J. Meeuwsen-de Boer and Willem Alides Kamps and Jan Jacob Schuringa and Eveline S.J.M. de Bont},
  journal={Molecular cancer research : MCR},
  year={2013},
  volume={11 4},
  pages={
          339-48
        }
}
Although most children with acute myeloid leukemia (AML) achieve complete remission, the relapse rate is 30% to 40%. Because it is thought that leukemia-initiating cells (LIC) are responsible for AML relapses, targeting these cells might improve outcome. Treatment of pediatric AML blasts with the receptor tyrosine kinase (RTK) inhibitor PTK787/ZK 222584 (PTK/ZK) induces cell death in vitro. However, the role of PTK/ZK inhibition on outgrowth of (pediatric) LICs is unknown. In this study, we… CONTINUE READING
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