Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance.

Abstract

The liver is frequently challenged by surgery-induced metabolic overload, viruses or toxins, which induce the formation of reactive oxygen species. To determine the effect of oxidative stress on liver regeneration and to identify the underlying signaling pathways, we studied liver repair in mice lacking the Nrf2 transcription factor. In these animals… (More)

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@article{Beyer2008ImpairedLR, title={Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance.}, author={Tobias A Beyer and Weihua Xu and Daniel Teupser and Ulrich auf dem Keller and Philippe Bugnon and Eberhard Hildt and Joachim Thiery and Yuet Wai Kan and Sabine Werner}, journal={The EMBO journal}, year={2008}, volume={27 1}, pages={212-23} }