Impaired lithocholate sulfation in the rhesus monkey: a possible mechanism for chenodeoxycholate toxicity.

@article{Gadacz1976ImpairedLS,
  title={Impaired lithocholate sulfation in the rhesus monkey: a possible mechanism for chenodeoxycholate toxicity.},
  author={Thomas Gadacz and Robert N. Allan and Eberhard A Mack and Alan Frederick Hofmann},
  journal={Gastroenterology},
  year={1976},
  volume={70 6},
  pages={1125-9}
}
Radioactive lithocholate was administered intravenously to female rhesus monkeys with an exteriorized enterohepatic circulation, and the chemical form of biliary radioactivity was defined by thin layer chromatography. Most radioactivity was excreted in bile in the form of unsulfated conjugates (77%), indicating impaired sulfation relative to published data for man. Defective sulfation of lithocholate, the major bacterial biotransformation product of chenodeoxycholic acid, can explain… CONTINUE READING

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