Impaired light chain allelic exclusion and lack of positive selection in immature B cells expressing incompetent receptor deficient of CD19.

@article{Shivtiel2002ImpairedLC,
  title={Impaired light chain allelic exclusion and lack of positive selection in immature B cells expressing incompetent receptor deficient of CD19.},
  author={Shoham Shivtiel and Nira Leider and Orit Sadeh and Zaki M. Kraiem and Doron Melamed},
  journal={Journal of immunology},
  year={2002},
  volume={168 11},
  pages={5596-604}
}
Positive signaling is now thought to be important for B cell maturation, although the nature of such signals has not yet been defined. We are studying the regulatory role of B cell Ag receptor (BCR) signaling in mediating positive selection of immature B cells. To do so, we use Ig transgenic mice (3-83Tg) that are deficient in CD19, thus generating a… CONTINUE READING