Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia.

@article{Sathyasaikumar2011ImpairedKP,
  title={Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia.},
  author={Korrapati V. Sathyasaikumar and Erin K. Stachowski and Ikwunga Wonodi and Rosalinda C. Roberts and Arash Rassoulpour and Robert Patrick McMahon and Robert M. Schwarcz},
  journal={Schizophrenia bulletin},
  year={2011},
  volume={37 6},
  pages={1147-56}
}
The levels of kynurenic acid (KYNA), an astrocyte-derived metabolite of the branched kynurenine pathway (KP) of tryptophan degradation and antagonist of α7 nicotinic acetylcholine and N-methyl-D-aspartate receptors, are elevated in the prefrontal cortex (PFC) of individuals with schizophrenia (SZ). Because endogenous KYNA modulates extracellular glutamate… CONTINUE READING