Impaired intrahepatic natural killer cell cytotoxic function in chronic hepatitis C virus infection.

@article{Varchetta2012ImpairedIN,
  title={Impaired intrahepatic natural killer cell cytotoxic function in chronic hepatitis C virus infection.},
  author={Stefania Varchetta and Dalila Mele and Stefania Mantovani and Barbara Oliviero and Eleonora Cremonesi and Serena Ludovisi and Giuseppe Michelone and Mario Alessiani and Riccardo Rosati and Marco Montorsi and Mario U. Mondelli},
  journal={Hepatology},
  year={2012},
  volume={56 3},
  pages={841-9}
}
UNLABELLED Hepatitis C virus (HCV) persistence in the host results from inefficiencies of innate and adaptive immune responses. Most studies addressing the role of innate immunity concentrated on peripheral blood (PB) natural killer (NK) cells, whereas only limited information is available on intrahepatic (IH) NK cells. We therefore examined phenotypic and functional features of IH and PB NK cells in paired liver biopsy and venous blood samples from 70 patients with chronic HCV infection and 26… CONTINUE READING
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